Classically trained but conditioned by rock, pop, and folk music, John Regan has also worked with Second City in London, Ontario and appeared as a solo artist across southwestern Ontario. He cites Joe Jackson, Tom Waits, Elton John, and Roy Bittan as influences.

In addition to performing with stars including Roger Hodgson (Supertramp) and Lawrence Gowan (Styx), Regan has performed with more than 50 orchestras across North America.